NCT00623857

Micronutrients and Child Health Study

Effects of Supplementation With Zinc and Other Micronutrients on the Health and Development of African Children

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 612 (actual)
• Sponsor: Wageningen University · Academic / Other
• Sex: All
• Age: 6 Months – 60 Months
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine to what extent supplementation with zinc and other micronutrients are efficacious in preventing malaria in young Tanzanian children.

Detailed description

Zinc is essential for the functioning of the immune system. Supplementation trials in Asia, Latin America, the Pacific and developed countries have shown that increasing zinc intake has great potential to control common infections in children, but the response to supplementation may be different in Africa, where the primary environmental challenge to children's health is malaria. Simultaneous supplementation with other potentially limiting nutrients may be required to overcome a lack of response when zinc is given alone. The project aims at measuring effects of daily oral supplementation with zinc and other micronutrients, given either alone or in combination, on malaria incidence and nutritional status, and on indicators of immunity.

Conditions

• Malaria

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Zinc	Daily oral supplementation with zinc, 10 mg, for an average of 60 weeks
DIETARY_SUPPLEMENT	Vitamins and minerals other than zinc	Daily supplementation with vitamin A, vitamin B1, vitamin B2, niacin, vitamin B6, folic acid, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K, iron, iodine, copper, selenium, magnesium and calcium; for an average of 60 weeks
DIETARY_SUPPLEMENT	Vitamins plus zinc and other minerals	Daily oral supplementation with zinc, vitamin A, vitamin B1, vitamin B2, niacin, vitamin B6, folic acid, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K, iron, iodine, copper, selenium, magnesium and calcium; for an average of 60 weeks
DIETARY_SUPPLEMENT	Placebo	Daily oral supplementation with placebo for vitamins and all minerals; for an average of 60 weeks

Timeline

• Start date: 2008-03-01
• Primary completion: 2009-03-01
• Completion: 2009-03-01
• First posted: 2008-02-26
• Last updated: 2014-11-17

Locations

1 site across 1 country: Tanzania