NCT00616486

rTMS in Treatment of Obsessive Compulsive Disorder (OCD)

A Multicentre, Double-blind, Randomized, Placebo-controlled Study Evaluating the Efficacy, Safety, and Clinical Outcomes of Low Frequency, Repetitive Transcranial Magnetic Stimulation (Over Supplementary Motor Area (SMA) Applied Bilaterally and Simultaneously) Versus Sham (Placebo rTMS) Treatment for 6 Weeks, When Added to a Stable Pharmacotherapy in Subjects With Obsessive Compulsive Disorder (OCD).

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Queen's University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Low frequency (1Hz) rTMS applied bilaterally and simultaneously over SMA for 6 weeks in addition to the standard treatment regimen for OCD, will lead to significant improvement in patients' symptoms. The clinical improvement detected by YBOCS, CGI and SF-36 QOLS scores will be statistically significant in active treatment group compared to sham (placebo) treatment group.

Conditions

• Obsessive Compulsive Disorder

Interventions

Type	Name	Description
DEVICE	repetitive transcranial magnetic stimulation	6 weeks of stimulation with RMT frequency 1Hz, intensity 110% of RMT for 20 minutes, 5 minutes of trains with 2 minutes of intra-train intervals to both SMA. Treatment will be given 5 times a week for 4 weeks, 3 times a week during Week 5 and 2 times a week during Week 6.
DEVICE	sham (placebo)	Sham treatment will mimic active treatment mentioned above.

Timeline

• Start date: 2008-01-01
• Primary completion: 2010-05-01
• Completion: 2012-11-01
• First posted: 2008-02-15
• Last updated: 2015-12-16

Locations

3 sites across 3 countries: Bulgaria, Canada, Turkey (Türkiye)