NCT00608725

Pathophysiology of Orthostatic Intolerance

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 260 (actual)
• Sponsor: Satish R. Raj · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to describe the mechanism of orthostatic intolerance, relying on cardiovascular physiological studies. The syndrome is of undetermined etiology, but the syndrome causes impairment of a number of young adults, females more than males, with symptoms of tachycardia, fatigue, lightheadedness, palpitations, blurred vision, chest discomfort, difficulty concentrating, and dizziness with the upright posture. It is believed that many different pathophysiological processes can give rise to this disorder.

Detailed description

The purpose of this study is to describe the mechanism of orthostatic intolerance, relying on cardiovascular physiological studies. The syndrome is of undetermined etiology, but the syndrome causes impairment of a number of young adults, females more than males, with symptoms of tachycardia, fatigue, lightheadedness, palpitations, blurred vision, chest discomfort, difficulty concentrating, and dizziness with the upright posture. It is believed that many different pathophysiological processes can give rise to this disorder. This is not a clinical trial in the classical sense, but an omnibus protocol to allow for disntinct and personalized pathophysiological testing.

Conditions

• Tachycardia
• Postural Orthostatic Tachycardia Syndrome

Interventions

Type	Name	Description
RADIATION	DAXOR	131-I-Human Serum Albumin Blood Volume Assessment Kit
PROCEDURE	QSweat	Quantitative Sweat Testing
DRUG	Intrinsic Heart Rate	Atropine 0.04 mg/kg IV in divided doses Propranolol 0.2 mg/kg IV in divided doses

Timeline

• Start date: 1996-12-01
• Primary completion: 2029-12-01
• Completion: 2029-12-01
• First posted: 2008-02-06
• Last updated: 2025-10-08

Locations

1 site across 1 country: United States