NCT00605605

Vascular Endothelial Protection Effects of Dextromethorphan

Anti-Inflammation & Vascular Endothelial Protection Effects of Dextromethorphan on Heavy Smoker

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: National Cheng-Kung University Hospital · Academic / Other
• Sex: Male
• Age: 30 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

To test the hypothesis that DM could have anti-inflammatory effect and thus achieve vascular protection effect on heavy smokers.

Detailed description

Dextromethorphan (DM), an ingredient widely used in antitussive remedies, had been reported to reduce the inflammation-mediated degeneration of neurons. We recently found that DM can prevent vascular remodeling and neuron injury in animal models of carotid ligation and cerebral ischemia injuries, respectively. It was believed that its action was through the anti-oxidant and NADPH pathway to protect brain cells. However, the mechanism and actual effect on human vascular protection remained unclear. To test the hypothesis that DM could have anti-inflammatory effect and thus achieve vascular protection effect on heavy smokers, this prospective study will be conducted to treat subjects with heavy smoking history with DM or not and evaluate the anti-inflammatory and the improvement of endothelial function.

Conditions

• Atherosclerosis
• Smoking
• Inflammation

Interventions

Type	Name	Description
DRUG	Dextromethorphan	120 mg/day, single once daily dose taken after breakfast by oral route

Timeline

• Start date: 2005-03-01
• Primary completion: 2005-12-01
• Completion: 2005-12-01
• First posted: 2008-01-31
• Last updated: 2008-01-31

Locations

1 site across 1 country: Taiwan