NCT00600795

Prognostic Value of Transforming Growth Factor-Beta 1 in Normal Pressure Hydrocephalus

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 21 (actual)
• Sponsor: Vanderbilt University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Correlation of cerebrospinal fluid levels of transforming growth factor beta-1 with functional improvements after insertion of ventriculoperitoneal shunt for normal pressure hydrocephalus

Detailed description

The goal of this research is to investigate a potential CSF biomarker of NPH as a new tool for both the diagnosis of NPH and prognosis of VPS placement. Transforming growth factor-b1 (TGF-b1) is a signaling molecule involved in three fundamental activities; suppression of cell proliferation, immunosuppression, and deposition of extracellular matrix through promotion of synthesis and inhibition of degradation.8 Previously, TGF-b1 had been implicated in the development of communicating hydrocephalus secondary to pre-term infant intraventricular hemorrhage9 and adult aneurysmal sub-arachnoid hemorrhage.10, 11 Recently, an investigation demonstrated elevated levels of TGF-b1 in patients with shunt-responsive NPH compared to non-NPH patients.12 The specific aims of this research proposal are to: 1. Correlate CSF levels of TGF-b1 with the clinical response of patients diagnosed with NPH to VPS placement. 2. Correlate CSF levels of TGF-b1 with optimal VPS pressure settings.

Conditions

• Normal Pressure Hydrocephalus

Interventions

Type	Name	Description
OTHER	CSF collection	CSF collection at time of VPS insertion

Timeline

• Start date: 2008-01-01
• Primary completion: 2011-06-01
• Completion: 2011-06-01
• First posted: 2008-01-25
• Last updated: 2017-04-04

Locations

1 site across 1 country: United States