NCT00595933

Comparing Over-the-counter Dry Mouth Remedies After Radiation

A Comparative Trial of Over-the-counter Dry Mouth Remedies for Dry Mouth After Radiation to the Head and Neck

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: University of Oklahoma · Academic / Other
• Sex: All
• Age: 13 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to compare the effectiveness of over-the-counter remedies for dry mouth.

Detailed description

Xerostomia (dry mouth) is the most common late complication of radiation therapy for head and neck cancers. When patients are cured or survive for several years, xerostomia often becomes quite bothersome; it affects their quality of life. This study compares the effectiveness of seven over-the-counter remedies, 2 rinses, 3 sprays and 2 chewing gums. A computer program will make random assignments so that the patient nor the physician will choose the order in which the products are tried. The remedies will be used for one week each and at the end of each period the patient will fill out a questionaire.

Conditions

• Xerostomia

Interventions

Type	Name	Description
OTHER	sugar-free chewing gum	Chew gum 4 times a day with additional allowances for as needed. Fill out daily questionaire and an end of week.
OTHER	chewing gum	Chew gum 4 times a day with additional allowances for as needed. Fill out daily questionaire and an end of week.
OTHER	mouth rinse	Rinse mouth 4 times a day with additional allowances for as needed. Fill out daily questionaire and an end of week questionaire
OTHER	mouth rinse	Rinse mouth 4 times a day with additional allowances for as needed. Fill out daily questionaire and an end of week.
DRUG	mouth spray	Spray mouth with mouth spray 4 times a day with additional allowances for as needed. Fill out daily questionaire and an end of week
DRUG	mouth spray	Spray mouth 4 times a day with additional allowances for as needed. Fill out daily questionaire and an end of week

Timeline

• Start date: 2005-03-01
• Primary completion: 2010-06-01
• Completion: 2010-06-01
• First posted: 2008-01-16
• Last updated: 2022-09-07

Locations

1 site across 1 country: United States