NCT00585299

Effects of Weight Loss on Hepatic and Muscle Lipid Content and on Insulin Sensitivity on Obese Adolescents With NAFLD

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 4 (actual)
• Sponsor: Yale University · Academic / Other
• Sex: All
• Age: 10 Years – 21 Years
• Healthy volunteers: Accepted

Summary

To assess whether reversal of fatty liver by moderate weight loss (8% of body weight) will lead to improvements in insulin sensitivity, which will be associated with changes in both glucose status and lipid profiles, in obese children and adolescents with fatty liver who have normal glucose or pre-diabetes.

Detailed description

This study will have two groups: one group that eats a moderate calorie, low-fat diet and is weighed regularly (every other week for 16 weeks) and the other who receives traditional diet therapy and returns in 16 weeks. Both groups will undergo procedures that test glucose tolerance and measure liver and muscle fat content before and after study period.

Conditions

• Fatty Liver
• Insulin Resistance

Interventions

Type	Name	Description
OTHER	Low-fat diet	20% calorie from fat diet followed for 8 weeks then maintenance diet for additional 8 weeks
OTHER	Traditional diet	Traditional low-fat diet with dietitian follow-up in 16 weeks

Timeline

• Start date: 2006-10-01
• Primary completion: 2010-06-01
• Completion: 2010-09-01
• First posted: 2008-01-03
• Last updated: 2014-06-17

Locations

1 site across 1 country: United States