NCT00559312

The Effect of Fluticasone/Salmeterol Combination on Exertional Breathlessness in Patients With Mild COPD

A 6-week Randomized, Double-blind, Placebo-controlled, Crossover Study to Assess the Effect of Fluticasone 250μg/Salmeterol 50μg Combination (FSC 250/50) on Exertional Dyspnea in Patients With Symptomatic Mild COPD

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: Queen's University · Academic / Other
• Sex: All
• Age: 41 Years
• Healthy volunteers: Not accepted

Summary

Even patients with milder COPD can have significant physiological abnormalities which become more pronounced during exercise, leading to intolerable breathing discomfort (dyspnea). While there is a compelling physiological rationale for the efficacy of inhaled corticosteroid/long-acting bronchodilator combination therapy \[i.e., fluticasone 250μg/salmeterol 50μg (FSC250/50)\] in moderate to severe COPD, little information is available on the potential impact of this therapy in milder symptomatic disease. This study will be the first to explore mechanisms of dyspnea and activity limitation in milder COPD and will determine if there is a sound physiological rationale for the use of FSC as therapy for this subpopulation.

Conditions

• COPD

Interventions

Type	Name	Description
DRUG	fluticasone/salmeterol combination	Diskus inhaler, fluticasone 250μg/salmeterol 50μg, twice daily, 6-week duration
DRUG	placebo	Placebo Diskus inhaler, twice daily, 6-week duration

Timeline

• Start date: 2007-12-01
• Primary completion: 2010-03-01
• Completion: 2010-04-01
• First posted: 2007-11-16
• Last updated: 2012-12-17

Locations

1 site across 1 country: Canada