NCT00553995

Effect of Salsalate on Bed Rest-Induced Vascular Dysfunction

Effect of Physical Inactivity on Endothelial Function

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Boston University · Academic / Other
• Sex: All
• Age: 18 Years – 64 Years
• Healthy volunteers: Accepted

Summary

Physical inactivity induces vascular dysfunction and glucose intolerance during five days of bed rest. This study will investigate the effects of salsalate on these responses. Subjects will be randomized to treatment with salsalate or placebo for four days prior to initiation of bed rest. Vascular function in the brachial artery will be determined by ultrasound prior to treatment and before and after the 5-day bed rest protocol. We hypothesize that treatment with salsalate will be associated with protection again the development of glucose intolerance and vascular dysfunction in this setting.

Conditions

• Insulin Resistance

Interventions

Type	Name	Description
DRUG	salsalate	Salsalate 3-4 grams per day as tolerated for nine days
DRUG	Placebo

Timeline

• Start date: 2008-05-01
• Primary completion: 2013-12-01
• Completion: 2014-12-01
• First posted: 2007-11-06
• Last updated: 2017-03-10

Locations

1 site across 1 country: United States