NCT00538616

Precedex Versus Propofol-Awakening for Reducing Brain Injury Expansion

A Phase IV Single Center Cross Over Clinical Study Comparing Two Different Sedations Strategies for Mechanically Ventilated Patients With Neurological Critical Illness

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 8 (actual)
• Sponsor: Carmelo Graffagnino · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to evaluate brain injury when two different drugs (propofol and precedex) are used to sedate patients who need a neurologic exam.

Detailed description

The hypothesis is that a neurologic exam performed when the subject has continuous infusion of precedex will result in less brain injury (where the lactate/pyruvate ratio indicates injury) then when a neurologic exam is performed on subjects receiving propofol, because that exam requires that the propofol infusion be stopped.

Conditions

• Brain Injury
• Intracranial Pressure

Interventions

Type	Name	Description
DRUG	Dexmedetomidine	in this crossover study, subjects will receive 6 hours of propofol and 6 hours of precedex (randomized crossover)
DRUG	Propofol	in this crossover study, subjects will receive 6 hours of propofol and 6 hours of precedex (randomized crossover)

Timeline

• Start date: 2008-01-01
• Primary completion: 2008-02-01
• Completion: 2010-04-01
• First posted: 2007-10-02
• Last updated: 2013-04-11
• Results posted: 2013-04-11

Locations

1 site across 1 country: United States