NCT00534677

The Safety & Efficacy of Terlipressin vs Octreotide for the Control of Variceal Bleed

Efficacy And Safety Of Terlipressin Vs Octreotide As Adjuvant Therapy In Bleeding Esophageal Varices

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 320 (actual)
• Sponsor: Aga Khan University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Terlipressin and Octreotide are two common agents used as adjuvants in the management of variceal bleeding. Both agents have been claimed equivalent to endoscopic therapy in randomized studies. There are no head to head clinical trials of these two agents available in the literature. We aimed to compare the efficacy and safety of Terlipressin and Octreotide in combination with Endoscopic Variceal band Ligation (EVL)in patients presenting with Esophageal Variceal Bleed (EVB).

Detailed description

The effectiveness of combining Endoscopic treatment with Octreotide or Terlipressin has not been prospectively studied in esophageal variceal hemorrhage (EVH). This prospective, randomized clinical trial will help us in better patient management more efficiently and cost effectively.

Conditions

• Portal Hypertension
• Cirrhosis
• Hematemesis
• Melena

Interventions

Type	Name	Description
DRUG	Terlipressin	2 mg stat \& then 1 mg q6h iv and Placebo of Octreotide
DRUG	Octreotide	Octreotide 50mcg/hr infusion \& a placebo of Terlipressin

Timeline

• Start date: 2004-05-01
• Completion: 2005-07-01
• First posted: 2007-09-26
• Last updated: 2007-12-05

Locations

1 site across 1 country: Pakistan