NCT00529607

Diagnostics for the Reperfusion Injury Following MI

New Imaging and Diagnostic Techniques for the Assessment of Reperfusion Injury in Myocardial Infarction.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: RWTH Aachen University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The primary purpose of this study is to correlate new cardiac imaging modalities (2D, 3D echocardiography, contrast echocardiography, strain analysis and cardiac MRI) to biochemical parameters as the L-arginine-nitric oxide pathway and inflammatory cascades to characterize the reperfusion injury following myocardial infarction and thus providing a basis for further diagnostic and therapeutic approaches.

Detailed description

By reperfusion of ischemic myocardium further tissue damage occurs (ischemia / reperfusion injury). Various contributing mechanisms have been discussed in experimental studies, e.g. disturbances in coronary microcirculation and consecutive induction of inflammatory cascades involving formation of reactive oxygen species. The ischemia / reperfusion injury causes diastolic and regional as well as global systolic dysfunction. The time course of the reperfusion injury within the first hours after reperfusion and its effects on the global geometry of the left ventricle have not been investigated so far. In the present study a comprehensive morphological and functional characterisation of the ischemia / reperfusion injury in the acute phase is performed. New cardiac imaging modalities (2D, 3D echocardiography, contrast echocardiography, strain analysis and cardiac MRI)and biochemical parameters including the L-arginine-nitric oxide pathway and inflammatory cascades are applied. Hereby morphological and biochemical markers for the functional recovery of myocardial function should be identified.

Conditions

• Reperfusion Injury

Interventions

Type	Name	Description
DRUG	contrast echocardiography	directly after PCI, at 24 h after PCI, before discharge and at 6 months
PROCEDURE	2D and 3D echocardiography	directly after PCI, at 24 h after PCI, before discharge and at 6 months
PROCEDURE	cardiac MRI	before discharge and after 6 months
PROCEDURE	blood sampling	routine lab work plus infarction and inflammation biomarkers 1: before PCI, after PCI, at 34 hours, at discharge, at 6 months 2 and 3: one blood sample in total before PCI in 2 and at any time in 3

Timeline

• Start date: 2007-09-01
• Primary completion: 2009-03-01
• Completion: 2009-03-01
• First posted: 2007-09-14
• Last updated: 2009-03-20

Locations

1 site across 1 country: Germany