NCT00528736

Plasma B-Type Natriuretic Peptide Concentrations in Preterm Infants < 28 Weeks

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 82 (actual)
• Sponsor: Charite University, Berlin, Germany · Academic / Other
• Sex: All
• Age: 24 Hours – 48 Hours
• Healthy volunteers: Not accepted

Summary

The aim of the study was to evaluate BNP in preterm infants \< 28 weeks on the second day of life, when it is still unknown, if a patent ductus arteriosus is hemodynamic significant or not. We hypothesized that high plasma BNP concentrations on day 2 are associated with the need of PDA intervention in the further course.

Detailed description

From the study infants blood samples (0.1ml) were collected in K-EDTA microtubes within 24 to 48 hours of age through umbilical artery catheter aspiration or routine venous puncture. The samples were spun at 7000 rpm for 3 minutes. Platelet-free plasma was stored at -20°C until BNP analysis of all collected samples was carried out. The BNP assay was performed using a fully automated immunoassay system ADVIA method for the Centaur System (Bayer Diagnostic Division). In preterm infants who were treated with indomethacin or surgical ligation we collected additional blood samples 2-4 hours before intervention and 24 hours after the completion of the ductus treatment.

Conditions

• Infant, Premature
• Ductus Arteriosus, Patent
• Natriuretic Peptide Brain

Timeline

• Start date: 2005-08-01
• Completion: 2007-04-01
• First posted: 2007-09-12
• Last updated: 2007-09-14

Locations

1 site across 1 country: Germany