NCT00528190

Treatment of Aspergillus Fumigatus (a Fungal Infection) in Patients With Cystic Fibrosis

Treatment of Aspergillus Fumigatus in Patients With Cystic Fibrosis: A Randomized, Double-blind, Placebo-Controlled Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 35 (actual)
• Sponsor: Ottawa Hospital Research Institute · Academic / Other
• Sex: All
• Age: 6 Years
• Healthy volunteers: Not accepted

Summary

This clinical trial will attempt to determine whether we can improve clinical outcomes for patients with cystic fibrosis who are infected with a fungus called Aspergillus fumigatus.

Detailed description

The aim of this study is to determine whether antibiotic treatment directed against Aspergillus Fumigatus will be effective at preventing respiratory exacerbations and improving pulmonary function in patients with cystic fibrosis(CF) who are chronically colonized/infected with aspergillus. This aim will be accompanied by means of a randomized, double-blind, placebo-controlled clinical trial incorporating two parallel treatment arms.

Conditions

• Cystic Fibrosis

Interventions

Type	Name	Description
DRUG	Itraconazole	Oral Itraconazole 5mg/kg/day or identical placebo for 24 weeks

Timeline

• Start date: 2007-10-01
• Primary completion: 2010-08-01
• Completion: 2011-05-01
• First posted: 2007-09-12
• Last updated: 2017-05-10
• Results posted: 2017-03-23

Locations

2 sites across 1 country: Canada