NCT00527995

Acute Effects of Sildenafil on Endothelial Function in People With Diabetes

Acute Effects of Sildenafil on Flow Mediated Dilatation and Cardiovascular Autonomic Nerve Function in Type 2 Diabetic Patients

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Ruhr University of Bochum · Academic / Other
• Sex: Male
• Age: 35 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

This is a double-blind, placebo-controlled, cross-over trial using a single dose of 100 mg sildenafil or placebo in 40 subjects with T2DM without known cardiovascular disease. Effects on haemodynamic parameters, flow mediated dilatation (FMD) in brachial artery, cardiovascular autonomic function tests, and spontaneous baroreflex sensitivity (BRS) were investigated.

Conditions

• Type 2 Diabetes Mellitus
• Endothelial Dysfunction

Interventions

Type	Name	Description
DRUG	Sildenafil	Orally administered, Sildenafil 100mg, unique administration

Timeline

• Start date: 2001-08-01
• Completion: 2003-06-01
• First posted: 2007-09-11
• Last updated: 2007-09-11

Locations

1 site across 1 country: Germany