NCT00471731

Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure

Ocular Impact of X Chromosome Karyotype and Sex Hormones in Turner Syndrome

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 72 (actual)
• Sponsor: National Eye Institute (NEI) · NIH
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Premature ovarian failure (POF) is known to be associated with an increased risk of ocular surface disease (dry eye), likely due to the reduction of both estrogens and androgens seen in this condition. From preliminary data, we suspect that women with Turners syndrome (45, XO), a genetic abnormality that affects sex hormone levels, are also at increased risk of ocular surface disease. Comparing POF and TS women may allow us to distinguish different mechanisms for ocular surface disease, due to the different etiologies of hormonal (estrogen and androgen) alterations posed by POF and TS.

Detailed description

Premature ovarian failure (POF) is known to be associated with an increased risk of ocular surface disease (dry eye), likely due to the reduction of both estrogens and androgens seen in this condition. From preliminary data, we suspect that women with Turners syndrome (45, XO), a genetic abnormality that affects sex hormone levels, are also at increased risk of ocular surface disease. Comparing POF and TS women may allow us to distinguish different mechanisms for ocular surface disease, due to the different etiologies of hormonal (estrogen and androgen) alterations posed by POF and TS.

Conditions

• Turner Syndrome
• Ovarian Failure, Premature
• Sex Chromosome Aberrations
• Menopause
• Perimenopause

Timeline

• Start date: 2007-05-07
• Completion: 2014-11-13
• First posted: 2007-05-10
• Last updated: 2018-02-14

Locations

1 site across 1 country: United States