NCT00465660

Resistive Exercise for Arthritic Cartilage Health (REACH)

The Effect of 6 Month High Intensity Progressive Resistance Training on Knee Articular Cartilage Morphology in Female Osteoarthritic Patients

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 60 (planned)
• Sponsor: University of Sydney · Academic / Other
• Sex: Female
• Age: 40 Years
• Healthy volunteers: Accepted

Summary

Female subjects over the age of 40 will be recruited and randomised into a progressive resistance training (PRT) or sham-exercise group. The PRT group will train at 80% of their peak strength, using Keiser pneumatic resistance machines, and progress approximately 3% per session. Strength will be re-assessed fortnightly. Exercises will target muscles around the hip and knee. The sham-exercise group will train on the same equipment as the PRT group except hip adduction, but without added resistance or progression. Both groups will train 3 days per week for roughly 45 minutes for 6 months. It is hypothesised that high intensity PRT will decelerate the tibial and femoral cartilage degeneration in the knee affected most by OA. Primary Outcome: Articular cartilage morphology following 6 months high intensity progressive resistance training Secondary Outcomes: Muscle and fat cross-sectional area (CSA) (pre and post) Muscle strength, power, endurance, and contraction velocity (pre, 3 months, \& post) Medications (pre, 3 months, \& post) Body composition (pre, 3 months, \& post) Balance; Physical function (pre, 3 months, \& post) Questionnaires (pre, 3 months, \& post) * Habitual exercise (PASE) -WOMAC index (pain, stiffness and functional ability) * Depressive symptoms (Depression Scale) -Quality of life (SF36) * Confidence performing physical activity (Ewart) -Demographics

Conditions

• Osteoarthritis

Interventions

Type	Name	Description
BEHAVIORAL	Progressive resistance training

Timeline

• Start date: 2005-04-01
• Completion: 2009-07-01
• First posted: 2007-04-25
• Last updated: 2007-04-25

Locations

1 site across 1 country: Australia