NCT00457938

Novel Therapies for Metabolic Complications of Lipodystrophies

Novel Therapies for Metabolic Complications in Patients With Lipodystrophies

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 4 (actual)
• Sponsor: University of Texas Southwestern Medical Center · Academic / Other
• Sex: All
• Age: 14 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Lipodystrophies represent a therapeutic challenge with regards to the management of the diabetes, insulin resistance, hypertriglyceridemia and fatty liver which frequently present in conjunction with significant adipose tissue loss. The purpose of the study and it's four subprojects is to examine the safety and efficacy of various novel interventions designed to improve or resolve the fatty liver, hypertriglyceridemia, and insulin resistance or diabetes that is seen in these patients.

Detailed description

We propose novel therapeutic approaches for the management of metabolic complications in patients with lipodystrophies. The four interventions to be tested are: Hypothesis 1: An extremely low fat diet.

Conditions

• Insulin Resistance
• Hypertriglyceridemia
• Diabetes
• Hepatic Steatosis

Interventions

Type	Name	Description
OTHER	low-fat diet ( Still recruiting )	This study will compare 10% fat versus 35% fat diets in terms if effect on liver fat, triglycerides adn other metabolic parameters.
OTHER	Diet	10 % versus 35 % fat in diet

Timeline

• Start date: 2006-04-01
• Primary completion: 2014-11-01
• Completion: 2014-11-01
• First posted: 2007-04-09
• Last updated: 2018-10-16

Locations

1 site across 1 country: United States