NCT00446420

Cognitive Impairment Following Sedation for Colonoscopy With Propofol, Midazolam and Fentanyl Combinations

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 200 (actual)
• Sponsor: Melbourne Health · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Our hypothesis is that adding midazolam and/or fentanyl to propofol sedation for elective outpatient colonoscopy increases cognitive impairment at hospital discharge without improving intraoperative conditions or reducing intraoperative side-effects. 200 healthy patients aged 18 years or older will be randomised to receive propofol or propofol plus midazolam and/or fentanyl. Cognitive impairment will be tested at hospital discharge using Cogstate computerised testing software.

Detailed description

A great variety of drug combinations are administered to patients having elective outpatient colonoscopy. In addition, as patients are going home, some may have residual cognitive deficits that making leaving the hospital unsafe. This study aims to find drugs combinations that are associated with the least cognitive impairment.

Conditions

• Cognitive Impairment

Interventions

Type	Name	Description
DRUG	Propofol, midazolam, fentanyl	All drugs administered in doses according to anaesthetists' discretion during sedation for colonoscopy

Timeline

• Start date: 2007-02-01
• Primary completion: 2008-02-01
• Completion: 2008-02-01
• First posted: 2007-03-12
• Last updated: 2013-05-30

Locations

1 site across 1 country: Australia