Trials / Completed
CompletedNCT00439491
Role of Adipose Tissue in Pathogenesis of Insulin Resistance
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 35 (planned)
- Sponsor
- Charles University, Czech Republic · Academic / Other
- Sex
- Female
- Age
- 18 Years – 60 Years
- Healthy volunteers
- Not accepted
Summary
The aim of the study was to investigate the relationship between insulin resistance and body composition in relation to secterion and expression of adipocytokines. Obese subjects undergo 6 months hypocaloric diet and, before, during and at the end of the diet, plasma samples and subcutaneous adipose tissue samples are obtained for subsequent analysis. In addition, body composition and insulin resistance are measured before and during the diet.
Detailed description
The aim of the study was to investigate the relationship between insulin resistance and body composition in relation to secterion and expression of adipocytokines. Obese subjects undergo 6 months hypocaloric diet without any medication and, before, during and at the end of the diet, plasma samples and subcutaneous adipose tissue samples are obtained for subsequent analysis. Adipose tissue samples are obtained using needle biopsy. In addition, before and during the diet,body composition is measured using multifrequency bioimpedance and insulin resistance is evaluated using either hyperinsulinemic clamp or glucose/insulin - derived indices.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BEHAVIORAL | Hypocaloric diet |
Timeline
- Start date
- 2004-01-01
- Completion
- 2006-12-01
- First posted
- 2007-02-23
- Last updated
- 2007-02-23
Locations
1 site across 1 country: Czechia
Source: ClinicalTrials.gov record NCT00439491. Inclusion in this directory is not an endorsement.