NCT00438061

Effect of Abdominal Obesity on Lipoprotein Metabolism

Effect of Weight Loss on Lipoprotein Metabolism in Abdominal Obesity

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 40 (planned)
• Sponsor: The University of Western Australia · Academic / Other
• Sex: Male
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Abdominal obesity is strongly associated with dyslipidemia, which may account for the associated increased risk of atherosclerosis and coronary disease. Weight reduction is suggested to be a preferred and effective first-line strategy to correct lipid abnormalities, particularly in overweight/obese subjects. This improvement may be related to the effect of reduction in abdominal fat mass on apoB and apoA-I metabolism, but this remains to be fully demonstrated. Hypothesis: Reduction in abdominal fat mass by weight loss decreases apoB concentration and raises HDL-cholesterol chiefly by increasing LDL-apoB fractional catabolic rate (FCR), as well as decreasing HDL apoA-I, respectively.

Detailed description

We examined the mechanism of the effect of weight loss through dieting on LDL and HDL metabolism in abdominally obese men. LDL apoB-100 and HDL apoA-I kinetics were studied using a primed-constant infusion of 1-\[13C\]-leucine in a controlled, dietary intervention trial of 16 weeks duration in middle-aged, obese men with the metabolic syndrome. Isotopic enrichment in apoB and apoA-I was measured by gas chromatography-mass spectrometry and fractional turnover rates estimated using multi-compartmental modelling.

Conditions

• Obesity
• Dyslipidemia
• Insulin Resistance

Interventions

Type	Name	Description
BEHAVIORAL	Weight loss by dietary restriction

Timeline

• Start date: 1995-01-01
• Completion: 1998-12-01
• First posted: 2007-02-21
• Last updated: 2007-02-26

Locations

1 site across 1 country: Australia