NCT00437177

Relationship Between D2 Receptors SPECT and the Apomorphine Test in Patients With OH Dependence (ALC-DRD2-APO)

Relationship Between D2 Receptors SPECT and the Apomorphine Test in Patients With OH Dependence: Predictive Value for Relapse

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Hospital Universitari Vall d'Hebron Research Institute · Academic / Other
• Sex: Male
• Age: 25 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

OH dependence is associated with DA receptor changes. Both, the apomorphine test and the D2Rec SPECt are usefull for monitoring DA receptor status. We aimed at studying whether DA receptor hypofunction, assessed by means of the apomorphine test and the D2Rec SPECT, is a marker of relapse in detoxified OH dependents patients.

Conditions

• Alcoholism

Interventions

Type	Name	Description
DRUG	apomorphine	Apomorphine 0.05 mg/kg subcutaneously at hospital admission and at discharge. Abstinent participants at 3 months will receive a third dose.
DRUG	[(123)I] iodobenzamide	\[(123)I\] iodobenzamide 185 MBq I.V., at discharge.

Timeline

• Start date: 2007-01-01
• Primary completion: 2009-12-01
• Completion: 2010-06-01
• First posted: 2007-02-19
• Last updated: 2009-04-29

Locations

1 site across 1 country: Spain