NCT00428857

Noninvasive Ventilatory Support After Lung Surgery in COPD Patients

Noninvasive Ventilatory Support After Lung Surgery to Prevent Pulmonary Complications in COPD Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 360 (actual)
• Sponsor: Assistance Publique - Hôpitaux de Paris · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Rationale: respiratory complications are the most frequent complications following lung resection and represent a noticeable cause of mortality. Benefits from non-invasive ventilation (NIV) in acute respiratory failure are now clearly demonstrated. The use of preventive NIV after lung resection, in the absence of acute respiratory failure and/or hypercarbia, could be justified by the physiological benefits expected. The goal of this study is to assess the efficacy of post-operative NIV in moderate-to-severe COPD, for prevention of respiratory complications. Material and Methods: This is a prospective randomised multicenter trial with an open parallel design in moderate-t-o-severe COPD patients hospitalised in thoracic surgery for lung resection. Expected results: This study will determine whether post-operative NIV decreases the incidence of acute respiratory events (acute respiratory failure) and whether some subgroups of patients benefit more from this strategy. Conclusion: This study should help evaluating the utility of post-operative NIV after lung resection.

Conditions

• COPD
• Post Pulmonary Resection

Interventions

Type	Name	Description
PROCEDURE	non invasive ventilation	non invasive ventilation

Timeline

• Start date: 2008-06-01
• Primary completion: 2010-10-01
• Completion: 2010-10-01
• First posted: 2007-01-30
• Last updated: 2011-02-24

Locations

7 sites across 1 country: France