NCT00422253

Dietary Advanced Glycation End-products and Insulin Resistance in Overweight and Obese Humans

Will Reduction in Dietary Advanced Glycation End- Products Reduce Chronic Low Grade Inflammation and Improve Insulin Sensitivity in Overweight and Obese Humans

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 27 (actual)
• Sponsor: Bayside Health · Other Government
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

We hypothesize that reduction in dietary advance glycation endproducts (AGE) intake will increase insulin sensitivity and normalise insulin secretion in overweight and obese individuals through reduction of chronic low grade inflammation. We propose to test this hypothesis by performing euglycemic hypeinsulinemic glucose clamp and intravenous glucose tolerance test before and after low AGE diet and normal Australian diet in a cross-over design. This study will provide information relevant to the development and prevention of type 2 diabetes.

Conditions

• Type 2 Diabetes
• Insulin Resistance
• Obesity

Interventions

Type	Name	Description
BEHAVIORAL	dietary intervention

Timeline

• Start date: 2006-11-01
• Primary completion: 2012-12-01
• Completion: 2012-12-01
• First posted: 2007-01-15
• Last updated: 2013-12-16

Locations

1 site across 1 country: Australia