NCT00415701

Effect of Etomidate on Hemodynamics and Adrenocortical Function After Cardiac Surgery

Effect of an Anesthetic Induction Dose of Etomidate on Hemodynamics and Adrenocortical Function After Cardiac Surgery

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 130 (estimated)
• Sponsor: Insel Gruppe AG, University Hospital Bern · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to evaluate the effect of a single dose of etomidate for patients undergoing cardiac surgery with the use of cardiopulmonary bypass (CPB) on post-CPB adrenocortical responsiveness, on requirements of hemodynamic support, and on use of intensive care resources.

Conditions

• Coronary Artery Disease
• Mitral Valve Regurgitation

Interventions

Type	Name	Description
DRUG	Etomidate	Single induction dose of etomidate 0.2%; total dose 0.15 mg/kg
DRUG	Propofol	Single induction dose of propofol 2%; total dose 1.5 mg/kg
DRUG	Hydrocortisone	Hydrocortisone 100 mg/2 ml: day of operation 3x, POD 1 2x, POD 2 1x
DRUG	NaCl 0.9%	NaCl 0.9% 2 ml; day of operation 3x, POD 1 2x, POD 2 1x
OTHER	Tetracosactin	Diagnostic test, Tetracosactin 250 microg iv

Timeline

• Start date: 2006-11-01
• Primary completion: 2009-12-01
• Completion: 2009-12-01
• First posted: 2006-12-25
• Last updated: 2010-03-04

Locations

1 site across 1 country: Switzerland