NCT00413348

Type 2 Diabetes and the Effect of Probiotics

Effect of Probiotics on Systemic Inflammation and Insulin Resistance in Type 2 Diabetics and Healthy Controls

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 48 (planned)
• Sponsor: Rigshospitalet, Denmark · Academic / Other
• Sex: Male
• Age: 25 Years – 80 Years
• Healthy volunteers: Accepted

Summary

Insulin-resistance in type 2 diabetes is associated with chronic inflammation. Anti-inflammatory actions might increase sensitivity to insulin. Since some probiotics have anti-inflammatory properties, ingestion of the probiotic bacteria Lactobacillus Acidophilus NCFM might increase insulin-sensitivity. The inflammatory response to endotoxin injection and the insulin-sensitivity is examined before and after four weeks ingestion of probiotics.

Detailed description

Numerous studies have shown an association between insulin-resistance in type 2 diabetes and chronic low-grade inflammation. Some probiotics have an anti-inflammatory properties. Ingestion of probiotics might therefore, due to this property, increase sensitivity to insulin. In this study type 2 diabetics (N=24) and healthy control (N=24) are given the probiotic bacteria Lactobacillus Acidophilus NCFM for four weeks. The anti-inflammatory effect is examined by evaluating the inflammatory response (White blood cell count, plasma-cytokines) to an iv injection of endotoxin (0,3 ng/kg) before and after the intervention. Also the insulin-sensitivity is measured with an hyperinsulinemic euglycemic clamp before and after L. acidophilus NCFM.

Conditions

• Type 2 Diabetes
• Healthy
• Endotoxemia

Interventions

Type	Name	Description
DRUG	Lactobacillus acidophilus NCFM

Timeline

• Start date: 2006-11-01
• Completion: 2007-12-01
• First posted: 2006-12-19
• Last updated: 2006-12-19

Locations

1 site across 1 country: Denmark