NCT00397319

Growth Hormone's Effect on the Cardiovascular System

The Role of Growth Hormone in Cardiovascular Health

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 26 (planned)
• Sponsor: Vanderbilt University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

To evaluate specific markers of cardiovascular risk before and after growth hormone replacement therapy in a population of growth hormone deficient adults, as compared to an age, gender, and BMI-matched healthy population.

Detailed description

Growth hormone deficiency (GHD) is associated with increased cardiovascular morbidity and mortality. The effects of such a deficiency include decreased exercise capacity and tolerance, impaired cardiac function, a central fat redistribution, increased peripheral arterial resistance, and an unfavorable lipid profile. These effects have been found to be reversed with appropriate replacement therapy with recombinant human growth hormone. We plan to utilize several experimental systems to further investigate the role of growth hormone (GH) in maintaining cardiovascular health. In particular, we would like to further understand the interaction of GH with Plasminogen-activator-inhibitor-1 (a major activator of the fibrinolytic system) as well as the role of GH in the maintenance of vascular function.

Conditions

• Growth Hormone Deficiency

Interventions

Type	Name	Description
DRUG	Growth Hormone

Timeline

• Start date: 2005-08-01
• Completion: 2006-12-01
• First posted: 2006-11-09
• Last updated: 2007-07-03

Locations

1 site across 1 country: United States