NCT00381186

Impact of 3-year Lifestyle Intervention on Postprandial Glucose Metabolism: the SLIM Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (planned)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: All
• Age: 40 Years – 70 Years
• Healthy volunteers: Accepted

Summary

To evaluate the effect of a 3-year diet- and exercise lifestyle intervention, based on general public health recommendations, on glucose tolerance, insulin resistance and metabolic cardiovascular risk factors in Dutch subjects with impaired glucose tolerance (IGT).

Detailed description

Objective To evaluate the effect of a 3-year diet- and exercise lifestyle intervention, based on general public health recommendations, on glucose tolerance, insulin resistance and metabolic cardiovascular risk factors in Dutch subjects with impaired glucose tolerance (IGT). Research design and methods 147 IGT subjects (75 male, 72 female) were randomized to the intervention group (INT) or control group (CON). 106 subjects (52 INT, 54 CON) completed 3 years of intervention. Annually, glucose, insulin and FFA concentrations were determined during fasting and after an oral glucose tolerance test, in addition to measurements of body weight, serum lipids, blood pressure and maximal aerobic capacity.

Conditions

• Impaired Glucose Tolerance
• Type 2 Diabetes

Interventions

Type	Name	Description
BEHAVIORAL	diet- and exercise intervention

Timeline

• Start date: 1999-02-01
• Completion: 2006-06-01
• First posted: 2006-09-27
• Last updated: 2016-11-09