NCT00376662

HRT Versus Etidronate for Osteoporosis and Fractures in Asthmatics Receiving Glucocorticoids.

HRT and/or Etidronate in the Prevention and Treatment of Osteoporosis and Fractures in Post-Menopausal Patients With Asthma Receiving Long-Term Oral and/or Inhaled Glucocorticoids:a Randomised Factorial Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 750 (planned)
• Sponsor: British Thoracic Society · Academic / Other
• Sex: Female
• Age: 0 Years – 59 Years
• Healthy volunteers: Not accepted

Summary

To determine and compare the effects of Hormone replacement therapy (HRT), etidronate, HRT plus etidronate and no treatment over 5 years in the prevention and treatment of glucocorticoid-induced osteoporosis and fractures in post-menopausal women with asthma.

Detailed description

Multicentre trial involving 13 hospitals in United Kingdom, with patients entered by 17 Consultant Chest Physicians. Consenting patients were randomised in a central office to either HRT, etidronate, HRT plus etidronate or no treatment. Information on the progress of the patients was requested by the co-ordinating office annually for 5 years after entry to the trial. Outcomes were measured as new symptomatic fractures,new or worsening morphometric fractures of the thoraco-lumbar spine and changes in bone mineral density.

Conditions

• Osteoporosis

Interventions

Type	Name	Description
DRUG	Hormone Replacement Therapy and Etidronate

Timeline

• Start date: 1992-08-01
• Completion: 2000-10-01
• First posted: 2006-09-15
• Last updated: 2006-09-15

Locations

2 sites across 1 country: United Kingdom