NCT00363571

The Effect of Glyceryl Trinitate and Diamox on Cerebral Haemodynamics.

The Effect of Glyceryl Trinitrate (GTN) and Diamox on Cerebral Haemodynamics Judged With the Help of 3-Tesla MRI.

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (planned)
• Sponsor: Danish Headache Center · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

After infusion / injection of Glyceryl trinitrate and Diamox it is wished to study the effect of drugs on the cerebral haemodynamics such as Cerebral blod flow and cerebral blod volume.

Detailed description

Experimental headache model open a unike opportunity to study the pathophysiological mechanisms behind headache in general and migrane in particular. Previous studies have used various techniques to study the cerebral haemodynamics as a basis for the headache pathophysiology. We wish to use a 3-Tesa MRI so study the cerebral haemodynamics after application of various pharmacological substances. The most used experimental headache model is the glyceryl trinitrate model (GTN). Where infusion of the NO donor GTN induces headache and changes in the cerebral arteries. On the other hand injection of Diamox (Acetazolamide) apparently causes increase of the cerebral blod flow with out dilation of the arteries. We wish to study the precise effect of GTN and diamox on the cerebral haemodynamics such as Cerebral blod flow (CBF) and Cerebral blod volume (CBV) via a 3-Tesla MRI.

Conditions

• Migraine

Interventions

Type	Name	Description
DRUG	GTN, Diamox

Timeline

• Start date: 2006-08-01
• Completion: 2007-05-01
• First posted: 2006-08-15
• Last updated: 2006-08-15

Locations

1 site across 1 country: Denmark