NCT00363532

Functional MRI (fMRI) in CGRP Induced Migraine

Functional MRI (fMRI) in Patients With Migraine Without Aura Provoked by

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (estimated)
• Sponsor: Danish Headache Center · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

In patients known with migraine without aura a migraine headache or migraine like headache will be induced by infusion of calcitonin gene related peptide (CGRP). The patients will then be stimulated with noxious heat via a thermode placed at the forehead. At the same time the Blood-oxygenation-level-dependent (BOLD) response will be measured via functional magnetic resonance imaging (fMRI), to estimate the central-nervous pain response. The regions of interest (ROI) will be thalamic region and medulla oblongata. Then the patients will be given pain relif in form of injection of sumatriptan and the effect of this will also be registered via measuring the BOLD response at the RIO's previously defined. A 3-Tesla MRI scanner will be used in this trail. This study will give us key knowledge of the trigeminal pain pathway and the central processing i.e sensitization during a migraine attach.

Conditions

• Migraine Without Aura

Interventions

Type	Name	Description
DRUG	infusion of calcitonin gene related peptide (CGRP)

Timeline

• Start date: 2006-09-01
• Primary completion: 2007-07-01
• Completion: 2007-07-01
• First posted: 2006-08-15
• Last updated: 2009-01-28

Locations

1 site across 1 country: Denmark