Trials / Terminated
TerminatedNCT00347035
INFLUENCE OF TOPICAL INDOMETHACIN ON HYPOTHENSIVE EFFECT OF BRIMONIDINE
- Status
- Terminated
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- —
- Sponsor
- Federal University of São Paulo · Academic / Other
- Sex
- All
- Age
- 18 Years – 90 Years
- Healthy volunteers
- —
Summary
Purpose: To evaluate the influence of the nonsteroidal anti-inflammatory indomethacin on the brimonidine intraocular pressure (IOP) lowering effect. Methods: A randomized double-masked study was carried out. Patients medicated with timolol maleate 0,5% and needed complementary medication were random allocated into two groups: (a) brimonidine tartarate 0,15% and indomethacin 1% or (b) brimonidine tartarate and placebo (balanced saline solution). If patient's both eyes were eligible, they were allocated to the same group. IOP was measured at two weeks, one month and two months after study beginning. The mean IOP of the eyes was used for analyzes, in the case of two eligible eyes. For statistical analyzes repeated measures analysis was used.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | brimonidine |
Timeline
- First posted
- 2006-07-04
- Last updated
- 2006-10-26
Source: ClinicalTrials.gov record NCT00347035. Inclusion in this directory is not an endorsement.