Trials / Terminated
TerminatedNCT00316576
Angiotensin-Converting Enzyme Polymorphism and Acute Renal Failure (ECAREA)
Evaluation of the Impact of the Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism on the Development of Acute Renal Failure in Critically Ill Patients
- Status
- Terminated
- Phase
- —
- Study type
- Observational
- Enrollment
- 160 (estimated)
- Sponsor
- University Hospital, Caen · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Associations between angiotensin-converting enzyme gene polymorphism and occurrence and outcome of ARDS, and with respiratory complications post cardiopulmonary bypass have already been demonstrated. Based on physiological effects of angiotensin II, we hypothesized that the I allele of the angiotensin-converting enzyme Insertion/Deletion polymorphism may be associated with a higher risk of acute renal failure in critically ill patients.
Detailed description
Associations between angiotensin-converting enzyme gene polymorphism and occurrence and outcome of ARDS, and with respiratory complications post cardiopulmonary bypass have already been demonstrated. Based on physiological effects of angiotensin II, we hypothesized that the I allele of the angiotensin-converting enzyme Insertion/Deletion polymorphism may be associated with a higher risk of acute renal failure in critically ill patients.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Blood sampling for PCR |
Timeline
- Start date
- 2006-05-01
- Completion
- 2006-11-01
- First posted
- 2006-04-21
- Last updated
- 2008-01-17
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT00316576. Inclusion in this directory is not an endorsement.