NCT00314080

Treatment of Survivors After Botulism Outbreak

An Outbreak of Botulism in Thailand: Clinical Manifestations and Management of Severe Respiratory Failure

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 18 (planned)
• Sponsor: Department of Medical Services Ministry of Public Health of Thailand · Other Government
• Sex: All
• Age: 1 Year
• Healthy volunteers: Not accepted

Summary

Background. Northern Thailand's biggest botulism outbreak to date occurred on 14 March 2006 and affected 209 people. Of these, 42 developed respiratory failure, and 25 of those who developed respiratory failure were referred to 9 high facility hospitals for treatment of severe respiratory failure and autonomic nervous system involvement. Among these patients, we aimed to assess the relationship between the rate of ventilator dependence and the occurrence of treatment by day 4 versus day 6 after exposure to bamboo shoots (the source of the botulism outbreak), as well as the relationship between ventilator dependence and negative inspiratory pressure. Methods. The investigators reviewed the circumstances and timing of symptoms following exposure. Mobile teams treated patients with botulinum antitoxin on day 4 or day 6 after exposure in Nan Hospital (Nan, Thailand). Eighteen patients (in 7 high facility hospitals) with severe respiratory failure received a low- and high-rate repetitive nerve stimulation test, and negative inspiratory pressure was measured.

Conditions

• Respiratory Failure
• Botulism

Interventions

Type	Name	Description
DRUG	Botulinum AntiToxin
PROCEDURE	neuro-electrophysiologic study, repetitive nerve stimulation
PROCEDURE	Protocol early weaning ventilator after recovery of repetitive nerve stimulation and stable negative inspiratory pressure

Timeline

• Start date: 2006-03-01
• Completion: 2006-04-01
• First posted: 2006-04-12
• Last updated: 2008-10-24

Locations

1 site across 1 country: Thailand