NCT00295412

The Impact of Quetiapine on the Drug Abuse Patterns of Addicted Schizophrenic Patients

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: —
• Sponsor: Université de Montréal · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: —

Summary

The lifetime of substance use disorders in schizophrenia is close to 50%. Substance abuse in schizophrenia is associated with negative consequences. Unfortunately, there no clear guidelines for the pharmacological treatment of this dual diagnosis population. Preliminary results suggest that second-generation antipsychotic drugs (mainly clozapine) may relieve drug cravings in schizophrenia. We performed a 12-week pilot study to evaluate the impact of quetiapine, a second-generation antipsychotic, on substance abuse parameters, psychiatric symptoms and side effects in patients schizophrenia and comorbid substance use disorders. Our expectation was a 20 % decrease in drug cravings from baseline to end-point.

Conditions

• Schizophrenia
• Substance Use Disorders

Interventions

Type	Name	Description
DRUG	quetiapine (drug)

Timeline

• First posted: 2006-02-23
• Last updated: 2006-02-23

Locations

1 site across 1 country: Canada