NCT00283595

Effect of Growth Hormone on Bone Metabolism in Anorexia Nervosa

Effect of Supraphysiological rhGH on Bone Metabolism in Patients With Anorexia Nervosa

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 21 (actual)
• Sponsor: Massachusetts General Hospital · Academic / Other
• Sex: Female
• Age: 14 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

Decreased bone strength is a serious medical problem present in many women with Anorexia Nervosa, or disordered eating. Women with weaker bones are more likely to suffer broken bones than women with normal bone strength. We are investigating whether a hormone that is naturally produced by the human body, called growth hormone, can help strengthen the bones of women with this type of disordered eating.

Detailed description

* Twelve week study * Eight visits, six of which can be conducted at your home physician's office * Two bone density scans * Hormonal and nutritional evaluations

Conditions

• Anorexia Nervosa
• Osteopenia
• Osteoporosis
• Eating Disorders

Interventions

Type	Name	Description
DRUG	Recombinant Human Growth Hormone	Dosage increased in steps for first four weeks. Self injection qd x 12 weeks
DRUG	Placebo for Recombinant Human Growth Hormone	Administered as Arm 1, rHGH active Injection qd x 12 weeks Dosage increase over four weeks

Timeline

• Start date: 2006-01-01
• Primary completion: 2009-02-01
• Completion: 2009-02-01
• First posted: 2006-01-30
• Last updated: 2020-09-02
• Results posted: 2012-10-16

Locations

1 site across 1 country: United States