NCT00264719

Metoclopramide to Aid Establishment of Breastfeeding:a Randomised Controlled Trial

Metoclopramide to Aid Establishment of Breastfeeding After Delivery: a Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 160 (estimated)
• Sponsor: National University Hospital, Singapore · Academic / Other
• Sex: Female
• Age: —
• Healthy volunteers: Accepted

Summary

Hypothesis: Early use of oral metoclopramide can hasten and improve the establishment of lactogenesis II in mothers after preterm and term deliveries. The study hopes to show that metoclopramide can be effective to establish and sustain Lactogenesis II for both preterm and term infants.

Detailed description

Hypothesis: Early Use of oral metoclopramide can hasten and improve the establishment of lactogenesis II in mothers after preterm and term deliveries. Metoclopramide(Maxolon) promotes lactation by antagonizing the release of dopamine in the central nervous system, thereby increasing prolactin levels, and thus inducing or augmenting breast milk levels. While Metoclopramide has commonly been used to augment breast milk production and relactation, its efficacy in helping to establish lactogenesis II has never been studied in a controlled clinical trial. If effective, it may become a valuable tool in aiding the successful establishment of breastfeeding, particularly in high risk groups such as mothers of preterm babies. If shown to be an effective galactogogue, the use of metoclopramide provides an inexpensive and safe means of establishing and sustaining lactogenesis II, indirectly improving the degree and duration of breastfeeding practiced by mothers of both term and preterm infants. The anticipated benefits are expected to be greatest for preterm infants and their mothers.

Conditions

• Breastfeeding

Interventions

Type	Name	Description
DRUG	Metoclopramide (Maxolon)	Mothers will be given metoclopramide 10 mg 3 times a day for 7 days, 2 times a day from day 8 to 10 and once a day from 11th to 12th day
DRUG	placebo	placebo 10 mg

Timeline

• Start date: 2006-01-01
• Primary completion: 2008-05-01
• Completion: 2009-05-01
• First posted: 2005-12-13
• Last updated: 2009-09-21

Locations

1 site across 1 country: Singapore