NCT00255775

Broccoli Sprout Extract in Preventing Lung Cancer in Smokers

Evaluation of the Biological Effects of Broccoli Sprout Extract in Smokers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (estimated)
• Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

RATIONALE: Chemoprevention is the use of certain drugs or substances to keep cancer from forming, growing, or coming back. The use of broccoli sprout extract may prevent lung cancer. PURPOSE: This clinical trial is studying how well broccoli sprout extract works in preventing lung cancer in smokers.

Detailed description

OBJECTIVES: Primary * Evaluate the effect of broccoli sprout extract on levels of DNA adducts in participants who smoke. * Determine the effectiveness of broccoli sprout extract in reducing tobacco-carcinogen induced DNA adducts in these participants. Secondary * Determine the effects of broccoli sprout extract on markers of the Nrf2 pathway in these participants. * Determine the effectiveness of broccoli sprout extract, in increasing the activity of the Nrf2 pathway, in these participants. * Evaluate the feasibility of using lymphocytes and buccal cells to monitor DNA adducts and changes in the Nrf2 pathway in these participants. OUTLINE: Participants are stratified according to GST genotypic polymorphism (M1 vs T1). Participants receive oral broccoli sprout extract daily for 3 weeks. Participants keep a daily diary of their eating and smoking habits for 3 weeks before, during, and for 3 weeks after study treatment. They must continue to smoke during the study, but are encouraged to quit after completing the study treatment. PROJECTED ACCRUAL: A total of 70 participants will be accrued for this study.

Conditions

• Lung Cancer

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	broccoli sprout extract
PROCEDURE	complementary or alternative medicine procedure

Timeline

• Start date: 2005-01-01
• Primary completion: 2009-05-01
• First posted: 2005-11-21
• Last updated: 2010-08-09

Locations

1 site across 1 country: United States