NCT00243451

Early Detection of Mild Cognitive Impairment in Individual Patients

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 34 (estimated)
• Sponsor: Louisiana State University Health Sciences Center Shreveport · Academic / Other
• Sex: All
• Age: 55 Years – 85 Years
• Healthy volunteers: Accepted

Summary

Our central hypothesis is that the early metabolic lesions of MCI can be reliably detected in individual subjects by objective analysis of \[18\]F-fluorodeoxyglucose (FDG) positron-emission tomography (PET) brain images, earlier and more accurately than by subjective clinician rating.

Detailed description

Our goal with this proposal is a prospective, longitudinal study that will examine subjects over a three-year span to establish the presence of MCI, evaluate progression of disease, and determine the validity of this method in detecting early MCI. Specifically, we predict that by using our Cognitive Decline Index (CDI) method of objective examination of FDG PET brain images from patients diagnosed with MCI or mild AD, we can accurately discriminate very early abnormalities in cerebral metabolism, and that this research method can be validated and translated into a clinically useful tool for the early detection of MCI. Our long-range goals are the development of methods and tools that enable the detection of pathology in individual patients at risk for cognitive impairment.

Conditions

• Mild Cognitive Impairment
• Mild Alzheimer's Disease

Interventions

Type	Name	Description
OTHER	PET scan & fMRI	Subjects will be screened and if applicable for the study will be scheduled for an MRI. At the third visit they will complete the PET scan. They will return at 6, 12, 24, and 36 months and complete another PET scan at the last visit.

Timeline

• Start date: 2003-09-01
• Primary completion: 2011-07-01
• Completion: 2011-07-01
• First posted: 2005-10-24
• Last updated: 2011-09-07

Locations

1 site across 1 country: United States