NCT00242450

Metoclopramide Use in Very Low Birth Weight Newborns

The Effect of Metoclopramide on Feeding in Very Low Birthweight Newborns : a Randomized, Double Blind, Placebo Controlled Pilot Study and a Proposal for a Multicentre Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 30 (planned)
• Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Academic / Other
• Sex: All
• Age: 72 Hours – 7 Days
• Healthy volunteers: Not accepted

Summary

During the first 7 days of life very small babies will receive the drug metoclopramide or a salt solution through an intravenous line. They will also begin to receive a very small amount of breast milk or formula within the first 72 hours of life, in addition toother nourishment that is provided by an intravenous line, according to standard hospital procedure. We think that the babies who receive the medication may reach full oral feeds than babies who receive the salt solution.

Detailed description

Clinically stable, premature babies (birth weight between 500 and 1,250g) will be randomized to receive metoclopramide (0.1 mg/kg IV q8h)or an equal volume of placebo for 7 days.A transition feeding schedule will begin within the first 72 hours of life. The time to full feeds for the 2 groups will be analyzed.

Conditions

• Infant, Premature

Interventions

Type	Name	Description
DRUG	Metoclopramide

Timeline

• Start date: 2002-03-01
• Completion: 2005-07-01
• First posted: 2005-10-20
• Last updated: 2017-08-25

Locations

1 site across 1 country: Canada