NCT00228254

Vitamin A and Zinc: Prevention of Pneumonia (VAZPOP) Study

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 2,582 (planned)
• Sponsor: Tufts University · Academic / Other
• Sex: All
• Age: 6 Months – 36 Months
• Healthy volunteers: Accepted

Summary

Children with malnutrition are often low in some nutrients, like zinc or vitamin A, that could help them fight off infections like pneumonia. Our study was designed to see if children who got supplements of zinc or vitamin A had fewer infections.

Detailed description

The Vitamin A and Zinc: Prevention of Pneumonia (VAZPOP) study was a multi-year nutritionally-stratified, placebo-controlled, double-blind study of low-dose vitamin A and/or zinc in 2,582 normal and malnourished urban children aged 6 to 36 months in Quito, Ecuador. Four group of \~ 645 children were enrolled in 2000, 2001, 2002, and 2003 with each child participating for up to 50 weeks. Children were visited 4 days each week. Outcome measures were pneumonia, other respiratory tract infections, diarrheal disease, and growth.

Conditions

• Pneumonia
• Diarrhea
• Acute Upper Respiratory Tract Infections

Interventions

Type	Name	Description
DRUG	Zinc (12.5 mg/day)
DRUG	vitamin A 10,000 IU per week

Timeline

• Start date: 2000-01-01
• Completion: 2004-06-01
• First posted: 2005-09-28
• Last updated: 2005-09-28

Locations

2 sites across 2 countries: United States, Ecuador