NCT00215280

Epidemiology and Control of Mansonella Perstans Infection in Uganda

Studies on the Epidemiology and Control of Mansonella Perstans Infection in Uganda

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 1,000 (planned)
• Sponsor: DBL -Institute for Health Research and Development · Academic / Other
• Sex: All
• Age: 5 Years
• Healthy volunteers: Accepted

Summary

Mansonella perstans (M. perstans) infection is widespread in Uganda. Knowledge about the epidemiology of this infection, and of the morbidity it induces is poor, and no effective treatment is available. The study aims at providing data on diagnostic, epidemiological, morbidity and treatment aspects of M. perstans infections in Uganda.

Detailed description

Overall objective: to investigate diagnostic, epidemiological and treatment aspects of M. perstans in Uganda with relevance to control Specific objectives: 1. To establish the pattern of diurnal periodicity of M. perstans microfilaraemia in humans 2. To establish the patterns of M. perstans microfilaraemia and possible clinical manifestations related to this infection in two communities with medium to high endemicity 3. To determine the efficacy of ivermectin alone and the combination of ivermectin and albendazole on M. perstans microfilaraemia.

Conditions

• Mansonelliasis
• Pruritus
• Lymphoedema
• Abdominal Pains

Interventions

Type	Name	Description
DRUG	ivermectin and albendazole

Timeline

• Start date: 2005-11-01
• Completion: 2006-02-01
• First posted: 2005-09-22
• Last updated: 2007-04-20

Locations

1 site across 1 country: Uganda