NCT00206375

Growth Hormone and GnRH Agonist in Adolescents With Acquired Hypothyroidism

Concomitant Use of Growth Hormone and GnRH Agonist in Adolescent Patients With Acquired Hypothyroidism

• Status: Terminated
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: Baylor College of Medicine · Academic / Other
• Sex: All
• Age: 8 Years – 17 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to see if giving growth hormone and Lupron along with thyroid hormone will improve final height in patients with long term hypothyroidism. Lupron is a medicine which is used to delay puberty and to prevent early closure of growing bones which might increase growth potential. Growth hormone is used to restore growth rate. This study will include children with "short term" and "long term" hypothyroidism.

Detailed description

Hypothyroidism is often associated with growth failure. It takes several years for slow growth to be noticed. This growth retardation is typically severe and progressive. Thyroid hormone is necessary for normal growth. Treatment with thyroxine (thyroid hormone) results in rapid catch-up growth, which mostly happens during the first 18 months. Growth is accompanied by increased bone age, which means early fusion (closure of the growing bones) of the bones and reduced growth potential. For example, a patient, who is 10 years old but has bone age of 12 years, has growth potential of a 12 year old and will stop growing 2 years earlier than a 10 year old patient. According to the literature, prolonged juvenile hypothyroidism (low thyroid condition) resulted in a permanent loss in height and only 70% catch-up growth was generally achieved with thyroxine replacement.

Conditions

• Hypothyroidism

Interventions

Type	Name	Description
DRUG	Growth hormone	Growth hormone + Synthroid + Lupron
DRUG	Growth hormone treatment and puberty	Lupron once a month and growth hormone daily

Timeline

• Start date: 2003-05-01
• Primary completion: 2011-09-01
• Completion: 2011-11-01
• First posted: 2005-09-21
• Last updated: 2020-10-30
• Results posted: 2020-10-30

Locations

1 site across 1 country: United States