Trials / Completed
CompletedNCT00200928
Asthma, a Disease Due to a Lack of Bacterial Infections in Childhood.
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 120 (planned)
- Sponsor
- The Netherlands Asthma Foundation · Academic / Other
- Sex
- All
- Age
- 0 Years
- Healthy volunteers
- Not accepted
Summary
The degree of TH1-skewing by mycobacteria is controlles by NRAMP1 gene polymorphisms and related to the degree of inhibition of TH2-mediated disease.
Detailed description
A randomised single blinded intervention study in high-risk newborns vaccinated at the age of 6 weeks with BCG or placebo. Inclusion: high-risk was defined as either a mother or a father and a sibling with present or past atopic disease. Exclusion: maternal infection in the last week of pregnancy, the use of immunomodulatory drugs or antibiotics during pregnancy (mother), the use of antibiotics directly post-partum (newborn)
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BIOLOGICAL | BCG |
Timeline
- Start date
- 1999-01-01
- Completion
- 2005-07-01
- First posted
- 2005-09-20
- Last updated
- 2006-04-04
Locations
1 site across 1 country: Netherlands
Source: ClinicalTrials.gov record NCT00200928. Inclusion in this directory is not an endorsement.