Trials / Completed
CompletedNCT00199069
German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93)
Multicenter Trial for Treatment of Acute Lymphoblastic Leukemia in Adults (05/93)
- Status
- Completed
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 720 (planned)
- Sponsor
- Goethe University · Academic / Other
- Sex
- All
- Age
- 15 Years – 65 Years
- Healthy volunteers
- Not accepted
Summary
The study evaluates the efficacy and tolerability of a risk- and subtype-adapted chemotherapy over one year, followed by randomized either intensified or conventional maintenance therapy. It includes a distinct protocol for the subgroup 'mature B-ALL',
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Asparaginase | |
| DRUG | Vincristine | |
| DRUG | Daunorubicin, Adriamycin | |
| DRUG | Cyclophosphamide | |
| DRUG | Ifosfamide | |
| DRUG | Cytarabine | |
| DRUG | Mitoxantrone | |
| DRUG | Methotrexate | |
| DRUG | 6-Mercaptopurine | |
| DRUG | 6-Thioguanine | |
| DRUG | VM26 | |
| DRUG | Dexamethasone / Prednisolone | |
| PROCEDURE | CNS Irradiation | |
| PROCEDURE | Mediastinal Irradiation | |
| PROCEDURE | Stem Cell Transplantation |
Timeline
- Start date
- 1993-04-01
- Primary completion
- 1999-01-01
- Completion
- 2001-05-01
- First posted
- 2005-09-20
- Last updated
- 2023-03-17
Locations
1 site across 1 country: Germany
Source: ClinicalTrials.gov record NCT00199069. Inclusion in this directory is not an endorsement.