Trials / Terminated
TerminatedNCT00190554
A Trial of Chemotherapy Before and After Surgery for Stage II,III Esophageal Squamous Cell Carcinoma
A Randomized Controlled Trial of Chemotherapy With 5FU and Cisplatin Before and After Surgery for Stage II,III Squamous Cell Carcinoma of the Thoracic Esophagus:JCOG9907
- Status
- Terminated
- Phase
- Phase 3
- Study type
- Interventional
- Enrollment
- 330 (planned)
- Sponsor
- Japan Clinical Oncology Group · Academic / Other
- Sex
- All
- Age
- 75 Years
- Healthy volunteers
- Not accepted
Summary
To determine whether chemotherapy before surgery makes better outcome than chemotherapy after surgery in patients with esophageal squamous cell carcinoma
Detailed description
The previous study JCOG9204 showed that postoperative adjuvant chemotherapy with cisplatin and fluorouracil has a detectable preventive effect on relapse in patients with esophageal squamous cell carcinoma compared with surgery alone.(J Clin Oncol 2003;21:4592-4596) Therefore the standard treatment for stage II and III esophageal cancer is adjuvant chemotherapy after surgery.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Surgery +(Cisplatin 80 mg/㎡+5FU 800mg/㎡×5days)×2 | |
| DRUG | (Cisplatin 80 mg/㎡+5FU 800mg/㎡×5days)×2＋Surgery |
Timeline
- Start date
- 2000-05-01
- Primary completion
- 2004-05-01
- Completion
- 2009-05-01
- First posted
- 2005-09-19
- Last updated
- 2016-09-22
Locations
24 sites across 1 country: Japan
Source: ClinicalTrials.gov record NCT00190554. Inclusion in this directory is not an endorsement.