Trials / Completed
CompletedNCT00185003
Blockade of Vascular Potassium Channels During Human Endotoxemia
- Status
- Completed
- Phase
- Phase 1
- Study type
- Interventional
- Enrollment
- 36 (actual)
- Sponsor
- Radboud University Medical Center · Academic / Other
- Sex
- All
- Age
- 18 Years – 35 Years
- Healthy volunteers
- Accepted
Summary
Background: Activation of NO-synthase and vascular potassium (K) channels may play a role in the sepsis-induced attenuated sensitivity to norepinephrine. We examined whether various K channel blockers and NO-synthase inhibition could restore norepinephrine sensitivity during experimental human endotoxemia.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | endotoxin | |
| DRUG | Potassium channel blockers: TEA, Quinin, Tolbutamide | |
| DRUG | L-NMMA |
Timeline
- Start date
- 2003-01-01
- Primary completion
- 2005-06-01
- Completion
- 2005-06-01
- First posted
- 2005-09-16
- Last updated
- 2008-10-17
Source: ClinicalTrials.gov record NCT00185003. Inclusion in this directory is not an endorsement.