NCT00167622

Early Mechanical Ventilation for Guillain Barré Syndrome

Efficacy and Safety of Preventive Mechanical Ventilation in Adults With Guillain Barré Syndrome

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: University of Versailles · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether early mechanical ventilation can prevent hospital acquired pneumonia in adults with Guillain Barré Syndrome.

Detailed description

Hospital acquired pneumonia is a common and severe complication of Guillain Barré Syndrome. Several factors have been recognized as predictors of respiratory failure in adults with Guillain Barré Syndrome. They include a time from disease onset and patient admission of less seven days, inability to lift head, impaired swallowing and a forced vital capacity of less than 60% of predictive value. We reasonned that early mechanical ventilation may prevent aspiration which is likely the main cause of pneumonia in these patients.

Conditions

• Guillain Barré Syndrome
• Acute Respiratory Failure

Interventions

Type	Name	Description
PROCEDURE	mechanical ventilation	Non invasive mechanical ventilation at least 6 hours per day - if difficult swallowing, tracheal intubation and invasive mechanical ventilation
PROCEDURE	physiotherapy and oxygen if needed	oxygen will be delivered via facial mask whenever needed and physiotherapy

Timeline

• Start date: 2005-04-01
• Primary completion: 2009-01-01
• Completion: 2009-02-01
• First posted: 2005-09-14
• Last updated: 2016-07-20

Locations

1 site across 1 country: France