NCT00158184

Prescription Opioid Effects in Abusers Versus Non-Abusers

Prescription Opioid Effects in Drug and Non-drug Abusers - 1

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 27 (actual)
• Sponsor: New York State Psychiatric Institute · Academic / Other
• Sex: All
• Age: 21 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to examine the abuse liability of oxycodone in individuals with, and without, a history of prescription opioid abuse.

Detailed description

Prescription opioid abuse is becoming an increasingly widespread and serious public health concern. The 2001 National Household Survey on Drug Abuse report revealed that the number of first-time users of prescription opioid medications for non-medical reasons reached 2 million in the year 2000, a number that has quintupled since 1984. Despite this trend, little experimental research has been directed towards understanding who may be abusing these medications, and under what conditions. The study will examine the reinforcing, subjective, performance, and physiological effects of oxycodone. Because it is not clear who is abusing prescription opioids, the medication effects will be compared in drug abusers and non-drug abusers.

Conditions

• Opioid-Related Disorders
• Substance-Related Disorders

Interventions

Type	Name	Description
DRUG	oxycodone 15 mg	15 mg/70 kg oxycodone administered once per day, orally.
DRUG	oxycodone 30 mg	30 mg/70 kg oxycodone administered once per day, orally.
DRUG	Placebo 0 mg	0 mg placebo dose administered once a day, orally.

Timeline

• Start date: 2004-06-01
• Primary completion: 2009-06-01
• Completion: 2009-06-01
• First posted: 2005-09-12
• Last updated: 2017-07-07
• Results posted: 2017-07-07

Locations

1 site across 1 country: United States