NCT00155402

The Application of Fibrin Glue in Ocular Surface Diseases

Phase 1 Study of Applying Fibrin Glue in Patients With Corneal Ulcer or Patients Requiring Wound Closure by Suture

• Status: Withdrawn
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: National Taiwan University Hospital · Academic / Other
• Sex: All
• Age: 3 Years
• Healthy volunteers: Not accepted

Summary

This clinical trial tries to use tissue fibrin glues (Tisseel) to treat various ocular surface diseases or surgeries, which includes pterygium surgery, corneal melting/perforation, Gunderson's flap, conjunctival laceration, and muscle/clinical/filtering surgery.

Detailed description

This clinical trial tries to use tissue fibrin glues (Tisseel) to treat various ocular surface diseases or surgeries. The inclusion criteria are: 1. ocular surface disease which may need amniotic membrane transplantation (corneal pro epithelization, pterygium surgery, etc) 2. infectious or noninfectious corneal ulcer with perforation less than 3 mm 3. conjunctival transplantation/suture 4. corneal surgeries which can be treated by conventional suture technique or application with cyanoacrylic acid tissue glues. Informed consents will be obtained from the patients before applications. After surgeries, topical steroids and antibiotics will be used, and therapeutic contact lens will be used. The patients will be followed up for at least three months.

Conditions

• Pterygium
• Corneal Ulcer

Interventions

Type	Name	Description
DRUG	tissue fibrin glue application (Tisseel)	Apply several droplets within several seconds to several minutes

Timeline

• Start date: 2005-04-01
• Completion: 2008-03-01
• First posted: 2005-09-12
• Last updated: 2008-05-29

Locations

1 site across 1 country: Taiwan